Never take your medications with grapefruit before checking with your pharmacist or physician. Drugs that interact with grapefruit juice Patients treated with certain medications may have to avoid other fruits and their juices (e.g., starfruit, pomegranate). Most citrus fruit, including lemons, sweet oranges (Navel or Valencia) and tangerines are considered safe. Seville oranges (used in marmalade), limes and pomelos may produce similar effects to grapefruit. To minimize the risk of drug interaction, refrain from eating grapefruits or drinking grapefruit juice if you are taking one of the following drugs. Not everyone will react the same way it depends on which drug is involved, the grapefruit itself, and how sensitive you are to these effects. Before starting any new medications, you should discuss potential drug and food interactions with your doctor or pharmacist. Grapefruit interactions are highly unpredictable. A substance in the grapefruit interacts with an enzyme that metabolizes these prescription medications, increasing the amount of medication in your blood to dangerously high levels. Drinking grapefruit juice in the morning, for example, and then taking your medication at night will not eliminate the risk of interaction. Because the effects of grapefruit last a long time, they cannot be avoided by spacing medication and grapefruit apart. The effects of grapefruit can last up to 3 days, sometimes even longer. Grapefruit contains substances that can interfere with the transformation and elimination mechanisms of certain drugs when they are administered orally, resulting in serious adverse reactions.Īs little as 200 mL of juice or a whole grapefruit can cause a significant increase of blood levels of certain drugs. Grapefruit juice can block the action of CYP3A4, so instead of being metabolized, more of the drug enters the blood and stays in the body longer. Also, your medicine container may have a sticker, warning of potential grapefruit interactions.ĭrug interactions are one of the reasons it’s important to tell your doctor and pharmacist of any vitamins, herbal or food supplements you are taking.Grapefruit and its juice (fresh or frozen) can either increase or, less frequently, decrease the effects of some drugs. This can be found in the medicines packet, or you can search for your medicine’s CMI online here. This should also be stated in the Consumer Medicines Information leaflet for your medicine. Your pharmacist or doctor will be able to advise you whether grapefruit or grapefruit juice will interact with your medicine. Possible interactions with whole grapefruit have not been evaluated but it would be assumed to have similar effects. How do I know if grapefruit juice will interact with my medicine? Sildenafil ( Viagra) used for erectile dysfunction.Calcium channel blockers, such as felodipine (e.g.Telfast) – in this case blood levels of fexofenadine go down and it becomes less effective. Some antihistamines, such as fexofenadine (e.g.Here are some common medicines that may interact with grapefruit. Lipitor) – the common lipid-lowering statin drug – is one of them. ![]() Research has shown that more than 85 medicines can interact with grapefruit, with 43 of them having potentially serious or deadly consequences. Common medicines that grapefruit juice interacts with ![]() Seville (or bitter) orange juice and limes may also cause the same effects as grapefruit. Consuming it regularly will make the chance of significant interactions more likely. ![]() The effect of grapefruit juice on some medicines can last for over 24 hours. It can happen even when the grapefruit is consumed at a different time from the medicine. Just one glass of grapefruit juice or one serve of grapefruit is all it takes to interfere with your medicine.
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